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Your Position: Home - Chemical Auxiliary Agent - Pd–Phosphine Precatalysts for Modern Cross-Coupling ...

Pd–Phosphine Precatalysts for Modern Cross-Coupling ...

Author: Evelyn y

May. 13, 2024

Pd–Phosphine Precatalysts for Modern Cross-Coupling ...

The development and use of well-defined preformed Pd catalysts are reviewed from academic and industrial points of view. The strategies employed for the development of Pd precatalysts resulting in either L2Pd(0) or LPd(0) are discussed with examples from industry and academia on how the properties of the ligand and the nature of the precatalyst itself can precisely affect the efficiency of a number of cross-coupling reactions. The well-defined preformed Pd catalysts often improve the selectivity and activity of selected cross-coupling reactions by reducing the metal loading and the ligand-to-metal ratios. In addition, they are often more practical to handle than the corresponding in situ system containing a Pd precursor such as Pd(dba)x and a pyrophoric ligand such as t-Bu3P.

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