The concept of a SARS-CoV-2 / COVID-19 rapid test
Oct. 07, 2024
The utilization of diagnostic and screening tests that emphasize speed, ease of use, and provide clear and reliable results is paramount in clinical environments. A lateral flow assay is a particular type of test that can identify specific analytes within a biological sample, such as pathogens or biomarkers. These assays are noted for their straightforward application and quick delivery of results concerning the presence or absence of the targeted analytes.
In the realm of COVID-19, most rapid tests employ sandwich immunoassay technology to identify the presence of SARS-CoV-2 particles. This technology operates by capturing viral antigens between a free labeled antibody and a stable second antibody – both of which are designed to recognize different parts of the antigen. Alternatively, the rapid anti-virus IgM/IgG tests adopt a similar methodology to detect human IgM and IgG antibodies generated in response to SARS-CoV-2 infection. This critical diagnostics tool helps determine whether an individual has been infected previously or is currently undergoing a viral infection, and it can offer insights into the stage of their illness.
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Table 1. COVID-19 Rapid Tests
Assay Type | Detection Target | Reagents Used in the Test | Clinical Significance |
---|---|---|---|
Rapid virus antigen test | SARS-CoV-2 nucleocapsid/spike protein | Nucleocapsid protein antibodies/ spike protein antibodies |
Ongoing viral production |
Rapid anti-virus IgM/IgG test | Anti-SARS-CoV-2 IgM and IgG antibodies | (1) Anti-human IgM and anti-human IgG antibodies (2) Labeled viral antigen (spike/nucleocapsid protein) |
Assessment of patient’s immune response to past or ongoing viral infection |
Figure 1: Relationship between the amount/type of antibody generated against SARS-CoV-2 and the clinical stage of COVID-19 disease.
(In some young people or special conditions, IgM may appear on the fourth day.)
How do COVID-19 Rapid Tests Work?
COVID-19 rapid test strip tests are equipped with a control line to verify the functionality of the test, alongside one or two test lines. The detection of analytes is qualitative and is assessed visually. Animated videos are available to illustrate the workings of the rapid test devices and the interactions within that yield the visible results.
1. For the SARS-CoV-2 rapid virus antigen test, you can view the process by clicking here. Figure 2 below illustrates the possible outcome readouts.
Figure 2: Possible result readouts of a SARS-CoV-2 rapid virus antigen test.
To discuss your needs for a strep a rapid test, please reach out to us. Our professional sales team is ready to assist you in choosing the best options for your requirements.
2. For the SARS-CoV-2 rapid anti-virus IgM/IgG test, you may view the testing mechanism by clicking here. The outcome options are depicted in Figure 3.
Figure 3: Possible result readouts of a SARS-CoV-2 rapid anti-virus IgM/IgG test.
GeneTex is pleased to present a comprehensive range of reagents aimed at facilitating the research of SARS-CoV-2/COVID-19. Refer to Tables 2, 3, and 4 below for an overview of GeneTex's antibodies, recombinant proteins, and cell pellet blocks presently available to support your SARS-CoV-2/COVID-19 research efforts.
Table 2. Antibodies for SARS-CoV-2 / COVID-19 Research
Clonality | Cat. No. | Product Name | Host | Applications |
---|---|---|---|---|
Recombinant | GTX | SARS-CoV-2 (COVID-19) Spike S1 antibody [HL1] | Rabbit | WB, ICC/IF, ELISA, sELISA |
Table 3. Recombinant Proteins for SARS-CoV-2 / COVID-19 Research
Cat. No. | Product Name |
---|---|
GTX-pro | SARS-CoV-2 (COVID-19) Spike S1 protein, His tag (active) |
Table 4. Cell Pellet Blocks for SARS-CoV-2 / COVID-19 Research
Cat. No. | Product Name |
---|---|
GTX | SARS-CoV-2 (COVID-19) Spike FFPE 293T cell pellet block |
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